Plant Steroids For Men & Women?
Good evening Ergos,
Let's have a chat about Ecdysterone.
WHAT IS ECDYSTERONE?
Ecdysterone is a type of ecdysteroid, which is a naturally occurring hormone found in certain plants and insects. In fact, the name “ecdysteroids” is a coined term: ‘ecdy’ is derived from ecdysis, which is the moulting process of insects before increasing in growth, and ‘steroids’ due to the four carbon ring polyhydroxylated ketosteroid base structure.
On a molecular level, ecysteriods are synthesized from dietary cholesterol once metabolised by cytochrome P450s. Then ecysteriods are understood to play an essential role in morphogenesis, which is the process required for tissue development. Fascinatingly, humans also have receptors for ecdysteroids, and when activated promote various health benefits, including muscle growth.
HOW DOES ECDYSTERONE WORK FOR MUSCLE GROWTH?
Scientists began to research ecysteriods to understand how this plant hormone has it’s anabolic abilities without significantly affecting hormonal activity in the body. They discovered that ecdysterone does not bind to androgen or estrogen receptor-alpha, but to estrogen receptor-beta (ERβ), and it is this activation that induces muscle hypertrophy, or put simply, an increase in muscle mass.
It may be surprising to hear that the activation of an estrogen related receptor to be beneficial in relation to bodybuilding, but ERβ plays a vital role in skeletal muscle growth (1). Ecdysterone has also been shown to accelerate muscle protein synthesis by stimulating the PI3K/Akt signaling pathway (2).
OLD SCHOOL RESEARCH
Researchers in Germany conducted a study which aimed to assess the effects of ecdysterone supplementation on human exercise performance. This 10 week intervention found ecdysterone to significantly increase muscle mass and even increase one rep max scores when compared to participants who did not supplement ecdysterone. Additionally there was no increase in liver and kidney toxicity (unlike steroids)(4). The data from this study indicates the effectiveness and safety of this supplement in regards to muscle growth acceleration and athletic performance. The scientific evidence has also shown Beta-Ecdysterone to induce hypertrophy of skeletal muscle to a similar degree to that of anabolic androgenic steroids, SARMS & IGF-1 (5).
The study outlined above by Parr MK et al. in 2015 does show that ecdysteroids increase strength and muscle mass whilst training, similar to other anabolic steroids.
DOSAGES
Most athletes use between 250mg-500mg per day. Since it does NOT suppress Testosterone or influence natural Estrogen metabolism, men and women can benefit from Ecdysterone, without suffering from major side effects.
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